PEA FOR TOPICAL USE
The lipophilic nature of PEA severely limits its solubility, both in water and in solvents and oil compounds. It is therefore a molecule with low bioavailability, a characteristic that complicates the development of its applications.
Alyval products contain a higher percentage of PEA compared to commonly used formulations; furthermore, the pealiquitech™ technology ensures maximum effectiveness.
Alyval uses a proprietary patent based on pealiquitech™ technology for the use of PEA in topical formulations.
Palmitoylethanolamide ( pea ) has been shown in numerous scientific studies to enhance the response of specific skin receptors and amplify the pharmacological effect of other active molecules, especially in the context of inflammation, pain, and neuroprotection.
This is the entourage effect
PEA
Palmitoylethanolamide (“PEA”) is a palmitic acid amide belonging to the class of ALIAmides* (endocannabinoid-like), lipid agonists of nuclear receptors. It is an endogenous molecule with local action, synthesised within the cell bilayer.
It is believed that PEA is produced as a pro-homeostatic protective response to cellular damage and is generally upregulated in disease states. Its diverse properties, including anti-inflammatory, analgesic, antimicrobial, immunomodulatory and neuroprotective effects, stem from unique mechanisms of action that influence numerous processes at different sites; these include the activation of nuclear receptor alpha by the peroxisome proliferator-activated receptor (PPAR-a) and other receptors, including cannabinoid receptors. In addition, PEA regulates transient receptor potential vanilloid 1 (TRPV1) channels, producing a significant desensitising effect.
ALIA
*ALIA = Autacoid Local Injury Antagonism - This is the acronym used by a team of Italian researchers, led by Nobel Prize winner for Medicine Rita Levi Montalcini, to identify a group of endogenous bioactive lipids (ALIAmides) that play a central role in numerous biological processes, including pain, inflammation and lipid metabolism (action on mast cells).
Comparison of images obtained with an optical microscope (100x magnification) showing: a conventional emulsion with high-concentration PEA (image 1) where the presence of undissolved crystals, not perceptible to the touch, is clear- an emulsion made with pealiquitechTM technology (image 2) where PERFECT SOLUBILISATION OF THE HIGH-CONCENTRATION ACTIVE INGREDIENT is clear.
THE USE OF PEA IN GYNAECOLOGY
