PEA FOR TOPICAL USE
The lipophilic nature of PEA severely limits its solubility in both water and oil-based solvents and compounds. It is therefore a molecule with low bioavailability, a characteristic that complicates the development of its applications. Alyval products have a higher percentage of PEA than is commonly used; in addition, pealiquitech™ technology ensures maximum availability and efficacy. Alyval uses a proprietary patent based on pealiquitech™ technology for the use of PEA in topical formulations.
Numerous scientific studies have shown that palmitoylethanolamide (PEA) enhances the response of specific skin receptors and amplifies the pharmacological effect of other active molecules, especially in the context of inflammation, pain and neuroprotection. This action is known as the “entourage effect”.
PEA
Palmitoylethanolamide (PEA) is a palmitic acid amide belonging to the class of ALIAmides (endocannabinoid-like), lipid agonists of nuclear receptors. It is an endogenous molecule with local action synthesised within the cell bilayer.
PEA is believed to be produced as a pro-homeostatic protective response to cellular damage and is generally over-regulated in states of stress. Its multiple actions, such as calming inflammation and discomfort, supporting defences and protecting cells, are due to its unique mechanisms of action that intervene in numerous processes at different sites. These include the activation of the nuclear alpha receptor by the peroxisome proliferator (PPAR-α) and other receptors, including cannabinoid receptors. In addition, PEA regulates the
transient receptor potential vanilloid 1 (TRPV1) receptor channels, helping to reduce sensitivity. In cosmetics, PEA has a powerful soothing and calming effect against all types of skin discomfort. Used as a functional ingredient, it can contribute to a feeling of local well-being.
ALIA
*ALIA = Autacoid Local Injury Antagonism - This is the acronym used by a team of Italian researchers, led by Nobel Prize winner for Medicine Rita Levi Montalcini, to identify a group of endogenous bioactive lipids (ALIAmides) that play a central role in numerous biological processes, including pain, inflammation and lipid metabolism (action on mast cells).
Comparison of images obtained with an optical microscope (100x magnification) showing: a conventional emulsion with high-concentration PEA (image 1) where the presence of undissolved crystals, not perceptible to the touch, is clear- an emulsion made with pealiquitechTM technology (image 2) where PERFECT SOLUBILISATION OF THE HIGH-CONCENTRATION ACTIVE INGREDIENT is clear.
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